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报告题目：Regulation of Natural Killer Cell Activation by SLAM-SAP Families
Introduction: NK cells play an essential role in immune-surveillance towards hematopoietic cells. This effect is mainly due to the distribution of ligands for SLAM family receptors, which are solely found on hematopoietic cells. NK cells express multiple SLAM family receptors, and they regulate NK cell activation through coupling SAP family adaptors, including SAP, EAT2 and ERT. The adaptor SAP, mutated in X-linked lymphoproliferative disease, has critical roles in multiple immune cell types. Amongst these, SAP is essential for the ability of natural killer (NK) cells to eliminate abnormal hematopoietic cells. SAP connects signaling stemmed from SLAM family mainly through its association with Fyn kinase, and SAP R78A mutation prevents efficiently recruitment of SAP with Fyn. However, how this protein regulates NK cell activation at molecular level remains unknown.I will summary our recent contributions to the field, and explain how SLAM-SAP families regulate NK cell activation andtheir surveillance againsthematopoietic cells.
 报告地点：7026am威尼斯科研楼5楼报告厅
报告时间：2012年4月9日14:00
报告人介绍：
董忠军博士，研究员，博士生导师，清华大学医学院肿瘤免疫学实验室负责人，2006年于中国科学技术大学获得细胞生物学博士学位，随后在加拿大蒙特利尔临床研究所从事博士后研究工作，2011年全职回国组建清华大学医学院肿瘤免疫学实验室。研究方向包括NK细胞功能获得的时空调节，SLAM-SAP家族蛋白调节NK细胞活化和NKT细胞发育的细胞和分子机制。实验室研究特色是采用基因修饰小鼠，结合现代免疫学和生物化学实验手段，在动物-细胞-分子三维水平揭示天然免疫细胞的发育、分化和活化等基础免疫学问题。
Related publications:
1. Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A*.SAP controls NK cell activation via a mechanism regulating Vav-1, SHIP-1 andLFA-1-dependent conjugate formation with target cells. Immunity,accepted.
2. Dong Z, Veillette A*. How do SAP family deficiencies compromise immunity?Trends in Immunology. 2010;31:295-302.
3. Dong Z, Cruz-Munoz ME, Zhong MC, Chen R, Latour S, Veillette A*. Essentialfunction for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nature Immunology. 2009;10:973-80. |
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